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Article

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.

Nucleic acids research - 20 Apr 2016

Malik Muhammad, Mustaev Arkady, Schwanz Heidi A, Luan Gan, Shah Nirali, Oppegard Lisa M, de Souza Ernane C, Hiasa Hiroshi, Zhao Xilin, Kerns Robert J, Drlica Karl

Abstract excerpt

Fluoroquinolones form drug-topoisomerase-DNA complexes that rapidly block transcription and replication. Crystallographic and biochemical studies show that quinolone binding involves a water/metal-ion bridge between the quinolone C3-C4 keto-acid and amino acids in helix-4 of the target proteins, GyrA (gyrase) and ParC (topoisomerase IV). A recent cross-linking study revealed a second drug-binding mode in which...

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Identifiers

PMID: 26984528
DOI: 10.1093/nar/gkw161
PMCID: PMC4838383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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