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Article

Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene.

Antimicrobial agents and chemotherapy - 1 Mar 1996

Kumagai Y, Kato J I, Hoshino K, Akasaka T, Sato K, Ikeda H

Abstract excerpt

Escherichia coli quinolone-resistant strains with mutations of the parC gene, which codes for a subunit of topoisomerase IV, were isolated from a quinolone-resistant gyrA mutant of DNA gyrase. Quinolone-resistant parC mutants were also identified among the quinolone-resistant clinical strains. Th...

Topics

Anti-Infective Agents
Base Sequence
Cloning, Molecular
Culture Media
DNA Topoisomerase IV
DNA Topoisomerases, Type II
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Infections
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ofloxacin

Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 8851598
DOI: 10.1128/AAC.40.3.710
PMCID: PMC163185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8851598-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene.PMID 8851598Read ↗

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Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.Semantic proximity Read ↗

Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in Enterococcus faecalisSemantic proximity Read ↗

Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

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Mutations in the quinolone resistance-determining regions of gyrA and parC in Enterobacteriaceae isolates from BrazilSemantic proximity Read ↗

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Ciprofloxacin-resistant Haemophilus influenzae strains possess mutations in analogous positions of GyrA and ParC.Semantic proximity Read ↗

ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype.Semantic proximity Read ↗

Analysis of mutational patterns in quinolone resistance-determining regions of GyrA and ParC of clinical isolatesSemantic proximity Read ↗

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