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Article

Mutations of the Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.

Molecular carcinogenesis - 1 Oct 2000

Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y

Abstract excerpt

Mutations of the Smad2 and Smad4 genes, identified as mediators of the transforming growth factor-beta pathway, were investigated in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. Male Wistar rats, 6 wk old, were given 2000 ppm BHP in their drinking water for 12 wk and maintained without additional treatment until killed at week 25. Total RNA was extracted from 12...

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Identifiers

PMID: 11074605
DOI: 10.1002/1098-2744(200010)29:2<87::aid-mc5>3.0.co;2-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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