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Article

Aberrant methylation patterns of the Rassf1a gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine.

Molecular carcinogenesis - 1 Feb 2006

Shimizu Kyoko, Kato Ayumi, Shigemura Mayumi, Fujii Hiromasa, Honoki Kanya, Tsujiuchi Toshifumi

Abstract excerpt

To clarify the involvement of the Rassf1a gene in lung carcinogenesis, we investigated the methylation status in the 5' upstream region of the RAS-association domain family 1, isoform A (Rassf1a) gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). Six-week-old male Wistar rats were given 2000 ppm BHP in their drinking water for 12 wk and maintained without further treatment until...

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PMID: 16329149
DOI: 10.1002/mc.20173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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