Article
Effect of acetylator genotype on 3,2'-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters.
Carcinogenesis - 1 Mar 1996
Paulsen J E, Steffensen I L, Namork E, Hein D W, Alexander J
Abstract excerpt
Aberrant crypt foci (ACF) are assumed to be preneoplastic lesions in both rodent and human carcinogenesis. The colon carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMAB), like other arylamines, undergoes N-acetylation and O-acetylation by polymorphic acetyltransferase (NAT2). In the present study we c...
Topics
- Acetylation
- Acetyltransferases
- Aminobiphenyl Compounds
- Animals
- Carcinogens
- Chlorides
- Colon
- Colonic Neoplasms
- Cricetinae
- Dimethyl Sulfoxide
- Genotype
- Male
- Mesocricetus
- Microscopy, Electron, Scanning
- Neoplasms, Experimental
- Precancerous Conditions