Article
Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.
Toxicology and applied pharmacology - 1 Jan 1994
Hein D W, Doll M A, Rustan T D, Gray K, Ferguson R J, Feng Y
Abstract excerpt
Congenic Bio. 1.5/H-NAT2 Syrian hamster lines were constructed by introducing the NAT2r gene from MHA/SsLak inbred hamsters into a background BIO 1.5 Syrian inbred hamster line. Genetic identity of the Bio. 1.5/H-NAT2 congenic lines and nonidentity with the previously constructed Bio. 82.73/H-Pat...
Topics
- Acetylation
- Acetyltransferases
- Animals
- Arylamine N-Acetyltransferase
- Base Sequence
- Biotransformation
- Carcinogens
- Cell Line
- Cricetinae
- Cytosol
- Female
- Fluorenes
- Genotype
- Liver
- Mesocricetus
- Molecular Sequence Data