Article
Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Ogolla F, Ferguson R J, Kirlin W G, Trinidad A, Andrews A F, Mpezo M, Hein D W
Abstract excerpt
Human epidemiological studies suggest an association between rapid acetylator phenotype and the incidence of colorectal cancer. Genetic regulation of acetyl coenzyme A-dependent N-acetyltransferase (NAT) and O-acetyltransferase (OAT) enzymatic activities may play a role in the metabolic activatio...
Topics
- Acetylation
- Acetyltransferases
- Acyltransferases
- Animals
- Arylamine N-Acetyltransferase
- Colon
- Cricetinae
- Cytosol
- DNA
- Gene Expression Regulation, Enzymologic
- Genotype
- In Vitro Techniques
- Intestines
- Liver