Article
Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.
Cancer research - 1 Feb 1993
Hein D W, Doll M A, Gray K, Rustan T D, Ferguson R J
Abstract excerpt
Acetylator genotype is regulated at the polymorphic acetyltransferase (NAT2) gene locus in humans and other mammals such as Syrian hamsters. Human slow acetylator phenotypes have been associated with increased incidences of urinary bladder cancers, whereas rapid acetylators have been associated with increased incidences of colorectal cancers. The genetic predisposition of rapid acetylators to colorectal cancers...
Topics
- Acetylation
- Acetyltransferases
- Amines
- Animals
- Biotransformation
- Carcinogens
- Colon
- Cricetinae
- Cytosol
- DNA
- Female
- Fluorenes
- Gene Expression Regulation, Enzymologic
- Genotype