Article
Acetylator genotype-dependent N-acetylation of arylamines in vivo and in vitro by hepatic and extrahepatic organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
Archives of toxicology - 1 Jan 1992
Hein D W, Rustan T D, Martin W J, Bucher K D, Miller L S, Furman E J
Abstract excerpt
Our laboratory recently reported the successful construction of homozygous rapid (Bio. 82.73/H-Patr) and homozygous slow (Bio. 82.73/H-Pat(s)) acetylator congenic Syrian hamsters. These hamsters are isogenic except for the polymorphic acetylator gene locus (Pat) and perhaps other closely linked loci. The purpose of the present investigation was to assess the expression of acetylator genotype both in vivo and in...
Topics
- Acetylation
- Amines
- Animals
- Arylamine N-Acetyltransferase
- Cricetinae
- Cytosol
- Female
- Gene Expression Regulation
- Genotype
- In Vitro Techniques
- Liver