Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.

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Article

Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.

Cancer research - 1 Feb 1996

Feng Y, Wagner R J, Fretland A J, Becker W K, Cooley A M, Pretlow T P, Lee K J, Hein D W

Abstract excerpt

Some but not all human epidemiological studies suggest a higher incidence of colon cancer in rapid acetylator individuals. Aberrant crypts, the earliest morphologically evident preneoplastic lesions in chemical colon carcinogenesis, were measured in rapid and slow acetylator congenic Syrian hamst...

Topics

Acetylation
Aminobiphenyl Compounds
Animals
Arylamine N-Acetyltransferase
Carcinogens
Cocarcinogenesis
Colonic Neoplasms
Cricetinae
Female
Genotype
Male
Mesocricetus
Precancerous Conditions

Source

Open in PubMed

Identifiers

PMID: 8564966

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8564966-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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