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Article

Mutational suppression of transferrin receptor shedding can be compensated by distinct metalloproteases acting on alternative sites.

FEBS letters - 11 Feb 2003

Dassler Katrin, Kaup Matthias, Tauber Rudolf, Fuchs Hendrik

Abstract excerpt

The human transferrin receptor (TfR) is proteolytically cleaved at R100 within the juxtamembrane stalk and to a lesser extent at an alternative site. We examined the effect of stalk mutations on human TfR shedding in transfected CHO cells. Point mutations at R100 led to an increase in alternative...

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PMID: 12586332
DOI: 10.1016/s0014-5793(03)00004-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12586332-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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