Article
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
The EMBO journal - 15 Dec 1998
Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E
Abstract excerpt
The ectodomains of many proteins located at the cell surface are shed upon cell stimulation. One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored form which is converted to a soluble form upon cell stimulation with TPA, an activator of protein...
Topics
- ADAM Proteins
- Catalytic Domain
- Disintegrins
- Epidermal Growth Factor
- Heparin-binding EGF-like Growth Factor
- Intercellular Signaling Peptides and Proteins
- Isoenzymes
- Membrane Proteins
- Metalloendopeptidases
- Muscle Proteins
- Mutation
- Protein Binding
- Protein Kinase C