Article
Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions.
European journal of immunology - 1 Apr 1996
Nepom G T, Ou D, Lybrand T P, DeWeese C, Domeier M E, Buckner J H, Mitchell L A, Tingle A J
Abstract excerpt
Antigen-specific and major histocompatibility complex (MHC)-restricted recognition by the T cell receptor involves multiple structural contacts over a large molecular surface area. Using a human T cell clone specific for a rubella viral peptide restricted by subsets of HLA DR4 molecules, we ident...
Topics
- Alleles
- Antigen Presentation
- Antigens, Viral
- Autoantigens
- CD4-Positive T-Lymphocytes
- HLA-DR Antigens
- HLA-DR4 Antigen
- HLA-DRB1 Chains
- Humans
- Lymphocyte Activation
- Models, Molecular
- Mutagenesis, Site-Directed
- Peptide Fragments
- Protein Binding
- Protein Conformation