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Article

Genomics-based identification of self-ligands with T cell receptor-specific biological activity.

Immunological reviews - 1 Dec 2002

Santori Fabio R, Brown Stuart M, Vukmanović Stanislav

Abstract excerpt

Self-peptide/major histocompatibility complex (MHC) complexes profoundly influence the biology of T lymphocytes. They promote the selection of the T cell receptor (TCR) repertoire in the thymus, maintain the homeostasis of peripheral T cells prior to encounter with antigen, and modify the responsiveness of T cells to foreign antigens. In addition, they can serve as antigens for autoaggressive T cells that induce...

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Identifiers

PMID: 12493012
DOI: 10.1034/j.1600-065x.2002.19011.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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