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Article

Functional analysis of a transactivation domain in the thyroid hormone beta receptor.

The Journal of biological chemistry - 9 Dec 1994

Tone Y, Collingwood T N, Adams M, Chatterjee V K

Abstract excerpt

Hormone-dependent transcriptional activation (AF-2) by the thyroid hormone beta receptor (TR beta) localizes to its carboxyl-terminal domain. A putative transactivation sequence within this domain was analyzed by mutating individual residues to alanine. Mutant receptor carboxyl-terminal domains were tested coupled to the heterologous DNA binding domain of Gal4. A single mutant receptor (E460A) showed normal...

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Source

Identifiers

PMID: 7983057

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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