Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand-independent and -dependent Functions of Thyroid Hormone Receptor Isoforms Depend upon Their Distinct Amino Termini

1 Jun 1995

Abstract excerpt

Isoform specificity likely plays a large role in the ability of the thyroid hormone receptor (TR) to specifically regulate gene expression in both the presence and absence of its cognate ligand, triiodothyronine. To investigate further the mechanism of isoform specificity of human TRs (TR alpha 1 and TR beta 1), we have examined their functional effects on positive thyroid hormone response elements (TREs) both in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Retinoids in leukemia and cellular processes
Share to Thyroid Disorders and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7782283
DOI: 10.1074/jbc.270.24.14274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ligand-independent and -dependent Functions of Thyroid Hormone Receptor Isoforms Depend upon Their Distinct Amino TerminiPMID 7782283Read ↗

The t4 Activation Domain of the Thyroid Hormone Receptor Is Required for Release of a Putative Corepressor(s) Necessary for Transcriptional SilencingSemantic proximity Read ↗

Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element.Semantic proximity Read ↗

The unique C-termini of the thyroid hormone receptor variant, c-erbA alpha 2, and thyroid hormone receptor alpha 1 mediate different DNA-binding and heterodimerization properties.Semantic proximity Read ↗

Negative and positive transcriptional regulation by thyroid hormone receptor isoforms.Semantic proximity Read ↗

Thyroid hormone receptors repress estrogen receptor activation of a TRE.Semantic proximity Read ↗

Distinct dimerization domains provide antagonist pathways for thyroid hormone receptor action.Semantic proximity Read ↗

Thyroid hormone receptor homodimers can function as ligand-sensitive repressors.Semantic proximity Read ↗

A Unique Role of the β-2 Thyroid Hormone Receptor Isoform in Negative Regulation by Thyroid HormoneSemantic proximity Read ↗

N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.Semantic proximity Read ↗

Molecular and structural biology of thyroid hormone receptors.Semantic proximity Read ↗

Cell type-dependent modulation of the dominant negative action of human mutant thyroid hormone beta 1 receptors.Semantic proximity Read ↗

Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.