Article
Decreased E-cadherin expression correlates with higher stage of Wilms' tumors.
Journal of pediatric surgery - 1 Feb 2005
Safford Shawn D, Freemerman Alex J, Langdon Scott, Bentley Rex, Goyeau Dominique, Grundy Paul E, Skinner Michael A
Abstract excerpt
PURPOSE: The aim of this study was to examine the association between E-cadherin expression and markers of Wilms' tumor aggression, including metastasis and recurrence. METHODS: Forty Wilms' tumor samples from the National Wilms' Tumor Study Group underwent immunohistochemical staining for E-cadherin. Tumor stage at diagnosis, recurrence, and loss of heterozygosity at 16q status was known for each of the tumor...
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