Article
SPN1, a conserved gene identified by suppression of a postrecruitment-defective yeast TATA-binding protein mutant.
Genetics - 1 Dec 2002
Fischbeck Julie A, Kraemer Susan M, Stargell Laurie A
Abstract excerpt
Little is known about TATA-binding protein (TBP) functions after recruitment to the TATA element, although several TBP mutants display postrecruitment defects. Here we describe a genetic screen for suppressors of a postrecruitment-defective TBP allele. Suppression was achieved by a single point mutation in a previously uncharacterized Saccharomyces cerevisiae gene, SPN1 (suppresses postrecruitment functions gene...
Topics
- Alleles
- Amino Acid Sequence
- Cell Cycle Proteins
- Cloning, Molecular
- Conserved Sequence
- Cytochrome c Group
- Cytochromes c
- Evolution, Molecular
- Genes, Fungal
- Molecular Sequence Data
- Multigene Family
- Mutation
- Phenotype
- Promoter Regions, Genetic