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Article

Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995

Sun Z W, Hampsey M

Abstract excerpt

Mutations in the Saccharomyces cerevisiae SSU71 gene were isolated as suppressors of a transcription factor TFIIB defect that confers both a cold-sensitive growth defect and a downstream shift in transcription start-site selection at the cyc1 locus. The ssu71-1 suppressor not only suppresses the conditional phenotype but also restores the normal pattern of transcription initiation at cyc1. In addition, the...

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Identifiers

PMID: 7724527
DOI: 10.1073/pnas.92.8.3127
PMCID: PMC42118

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Related research

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Research trail→

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Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae.PMID 7724527Read ↗

Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo.Semantic proximity Read ↗

Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of sua7 mutations defines a domain of TFIIB involved in transcription start site selection in yeast.Semantic proximity Read ↗

The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.Semantic proximity Read ↗

Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB.Semantic proximity Read ↗

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeastSemantic proximity Read ↗

A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing.Semantic proximity Read ↗

Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1.Semantic proximity Read ↗

Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

A suppressor of mutations in the class III transcription system encodes a component of yeast TFIIIB.Semantic proximity Read ↗

Carboxy-terminal region of the yeast heat shock factor contains two domains that make transcription independent of the TFIIH protein kinase.Semantic proximity Read ↗

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