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The multifaceted role of MyoD in adult skeletal muscle: homeostasis, regeneration, and diseases

5 Jun 2025

Abstract excerpt

Myogenic regulatory factors, including myoblast determination protein 1 (MyoD1 or MyoD) and myogenic factor 5 (Myf5), crucially regulate skeletal muscle lineage specification and development. Although MyoD and Myf5 exhibit overlapping functions during embryogenesis, their roles significantly diverge in adult muscles. Single MyoD knockout analysis revealed that MyoD uniquely regulates adult muscle regeneration,...

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PMID: 40471892
DOI: 10.1152/ajpcell.00334.2025

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