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Article

Absence of mutations at the activated protein C cleavage sites of factor VIII in 125 patients with venous thrombosis.

British journal of haematology - 1 Mar 1996

Roelse J C, Koopman M M, Büller H R, ten Cate J W, Montaruli B, van Mourik J A, Voorbert J

Abstract excerpt

Resistance to activated protein C (APC), caused by a mutation at amino acid position Arg506 of the factor V gene, has recently been identified as the most prevalent genetic defect associated with venous thrombosis. Similarly to factor V, mutations at the cleavage sites of factor VIII for APC may occur in patients with venous thrombosis. Here we have analysed 125 consecutive patients with incidental or recurrent...

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Source

Identifiers

PMID: 8616046
DOI: 10.1046/j.1365-2141.1996.349885.x

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Absence of mutations at the activated protein C cleavage sites of factor VIII in 125 patients with venous thrombosis.PMID 8616046Read ↗

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.Semantic proximity Read ↗

Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Low level of circulating activated protein C is a risk factor for venous thromboembolism.Semantic proximity Read ↗

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.Semantic proximity Read ↗

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Factor V Arg306-->Thr (factor V Cambridge) and factor V Arg306-->Gly mutations in venous thrombotic disease.Semantic proximity Read ↗

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.Semantic proximity Read ↗

Evaluation of original and modified APC-resistance tests in unselected outpatients with clinically suspected thrombosis and in healthy controls.Semantic proximity Read ↗

Mutations at the activated protein C cleavage sites Arg336 and Arg562 of factor VIII in Thai patients with venous thrombosis.Semantic proximity Read ↗

Co-segregation of thrombosis with the factor V Q506 mutation in an extended family with resistance to activated protein C.Semantic proximity Read ↗

Search for mutations in the genes for coagulation factors V and VIII with a possible predisposition to activated protein C resistance.Semantic proximity Read ↗

High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis.Semantic proximity Read ↗

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