Article
Mutations at the activated protein C cleavage sites Arg336 and Arg562 of factor VIII in Thai patients with venous thrombosis.
The Southeast Asian journal of tropical medicine and public health - 1 Dec 2001
Prayoonwiwat W, Arnutti P, Nathalang O, Suwanasophon C, Viputtigul K
Abstract excerpt
Venous thrombosis is a multicausal disease, more than one genetic risk factor may cooperate to effect thrombotic risk. Factor V Leiden is found to be an important hereditary risk factor for venous thromboembolism. Analogous to factor V Leiden, a point mutation at amino acid positions Arg336 and Arg562 in factor VIII may predispose patients to thrombosis. Eighty-one Thai patients with venous thrombosis and 100...
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