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Article

Search for mutations in the genes for coagulation factors V and VIII with a possible predisposition to activated protein C resistance.

European journal of clinical investigation - 1 Apr 1997

Bokarewa M I, Falk G, Bremme K, Blombäck M, Wiman B

Abstract excerpt

A total of 74 non-pregnant women with a previous episode of thrombosis were investigated for activated protein C (APC) resistance in the aPTT-based and factor IXa-X-based assays and for the presence of mutations in all APC-cleavage sites in the heavy chains of factor V and factor VIII. DNA fragments were amplified with the polymerase chain reaction (PCR) and those encoding for the Arg-306 and Arg-506 (factor V)...

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Source

Identifiers

PMID: 9134384
DOI: 10.1046/j.1365-2362.1997.1180660.x

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Search for mutations in the genes for coagulation factors V and VIII with a possible predisposition to activated protein C resistance.PMID 9134384Read ↗

Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.Semantic proximity Read ↗

Congenital and acquired activated protein C resistance.Semantic proximity Read ↗

Factor V Leiden and activated protein C resistance.Semantic proximity Read ↗

Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.Semantic proximity Read ↗

Activated protein C resistance and the FV:R506Q mutation in a random population sample--associations with cardiovascular risk factors and coagulation variables.Semantic proximity Read ↗

Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis.Semantic proximity Read ↗

Frequency of polymorphisms in the B-domain of factor V gene in APC-resistant patients.Semantic proximity Read ↗

[Activated protein C resistance as a cause of thrombophilia].Semantic proximity Read ↗

[Analysis of phenotype resistance to activated protein C (APC resistance)].Semantic proximity Read ↗

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