Article
A hemoglobin-binding outer membrane protein is involved in virulence expression by Haemophilus ducreyi in an animal model.
Infection and immunity - 1 May 1996
Stevens M K, Porcella S, Klesney-Tait J, Lumbley S, Thomas S E, Norgard M V, Radolf J D, Hansen E J
Abstract excerpt
Haemophilus ducreyi exhibits a requirement for exogenously supplied heme for aerobic growth in vitro. Nine of ten wild-type isolates of H. ducreyi were shown to contain a readily detectable hemoglobin-binding activity. Spontaneous hemoglobin-binding-negative mutants of two of these wild-type isolates lost the ability to express an outer membrane protein with an apparent molecular mass of approximately 100 kDa....
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