Article
DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers.
Infection and immunity - 1 Mar 2001
Bong C T, Throm R E, Fortney K R, Katz B P, Hood A F, Elkins C, Spinola S M
Abstract excerpt
Haemophilus ducreyi produces an outer membrane protein called DsrA, which is required for serum resistance. An isogenic dsrA mutant, FX517, was constructed previously in H. ducreyi 35000. Compared to its parent, FX517 cannot survive in normal human serum. When complemented in trans with a plasmid containing dsrA, FX517 is converted to a serum-resistant phenotype (C. Elkins, K. J. Morrow, Jr., and B. Olsen,...
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