Article
Outer membrane protein DsrA is the major fibronectin-binding determinant of Haemophilus ducreyi.
Infection and immunity - 1 Apr 2008
Leduc Isabelle, White C Dinitra, Nepluev Igor, Throm Robert E, Spinola Stanley M, Elkins Christopher
Abstract excerpt
The ability to bind extracellular matrix proteins is a critical virulence determinant for skin pathogens. Haemophilus ducreyi, the etiological agent of the genital ulcer disease chancroid, binds extracellular matrix components, including fibronectin (FN). We investigated H. ducreyi FN binding and report several important findings about this interaction. First, FN binding by H. ducreyi was greatly increased in...
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