Role of the Haemophilus ducreyi Ton system in internalization of heme from hemoglobin.

doi:10.1128/IAI.66.1.151-160.1998

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Article

Role of the Haemophilus ducreyi Ton system in internalization of heme from hemoglobin.

Infection and immunity - 1 Jan 1998

Elkins C, Totten P A, Olsen B, Thomas C E

Abstract excerpt

By cloning into Escherichia coli and construction of isogenic mutants of Haemophilus ducreyi, we showed that the hemoglobin receptor (HgbA) is TonB dependent. An E. coli hemA tonB mutant expressing H. ducreyi hgbA grew on low levels of hemoglobin as a source of heme only when an intact H. ducreyi Ton system plasmid was present. In contrast, growth on heme by the E. coli hemA tonB mutant expressing hgbA was...

Topics

Aldehyde Oxidoreductases
Alleles
Amino Acid Sequence
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
Cloning, Molecular
DNA, Bacterial
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haemophilus ducreyi

Heme

Hemin

Hemoglobins

Iron

Membrane Proteins

Molecular Sequence Data

Source

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Identifiers

PMID: 9423852
DOI: 10.1128/IAI.66.1.151-160.1998
PMCID: PMC107871

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