Article
Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system.
Infection and immunity - 1 May 2003
Ward Christine K, Latimer Jo L, Nika Joseph, Vakevainen Merja, Mock Jason R, Deng Kaiping, Blick Robert J, Hansen Eric J
Abstract excerpt
Haemophilus ducreyi 35000HP contains two genes, lspA1 and lspA2, whose predicted protein products have molecular weights of 456,000 and 543,000, respectively (C. K. Ward, S. R. Lumbley, J. L. Latimer, L. D. Cope, and E. J. Hansen, J. Bacteriol. 180:6013-6022, 1998). We have constructed three H. ducreyi 35000HP mutants containing antibiotic resistance cartridges in one or both of the lspA1 and lspA2 open reading...
Topics
- Agglutination
- Amino Acid Sequence
- Animals
- Bacterial Adhesion
- Bacterial Proteins
- Cell Line
- Haemophilus ducreyi
- Hemagglutinins
- Humans
- Lectins
- Models, Animal
- Molecular Sequence Data
- Mutation