Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation.

Blood - 1 May 1996

Perkins G R, Marshall C J, Collins M K

Abstract excerpt

Expression of a dominant interfering mutant of MAP kinase kinase (MAPKK) inhibits interleukin-3 (IL-3) activation of MAP kinase in the murine bone marrow-derived cell line BAF3. This results in an increase in the level of IL-3 required to stimulate cell proliferation and suppress apoptosis. When apoptosis is constitutively inhibited by coexpression of bcl-2, the dominant interfering MAPKK inhibits IL-3 driven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Line
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-3

Share to Mitogen-Activated Protein Kinase Kinases

Share to Mutation

Share to Protein Kinases

Source

Identifiers

PMID: 8611691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation.PMID 8611691Read ↗

Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation.Semantic proximity Read ↗

Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB.Semantic proximity Read ↗

Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells.Semantic proximity Read ↗

Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis.Semantic proximity Read ↗

Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts.Semantic proximity Read ↗

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).Semantic proximity Read ↗

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.Semantic proximity Read ↗

Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype.Semantic proximity Read ↗

Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells.Semantic proximity Read ↗

IL-4-dependent proliferation of BA/F3 cells expressing a growth-negative mutant of the human IL-4 receptor is restored by enforced expression of Bcl-2.Semantic proximity Read ↗

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.Semantic proximity Read ↗

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.