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Article

Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis.

The Journal of biological chemistry - 6 Apr 2001

Mathieu A L, Gonin S, Leverrier Y, Blanquier B, Thomas J, Dantin C, Martin G, Baverel G, Marvel J

Abstract excerpt

Baf-3 cells are dependent on interleukin-3 (IL-3) for their survival and proliferation in culture. To identify anti-apoptotic pathways, we performed a retroviral-insertion mutagenesis on Baf-3 cells and selected mutants that have acquired a long term survival capacity. The phenotype of one mutant, which does not overexpress bcl-x and proliferates in the absence of IL-3, is described. We show that, in this mutant,...

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Source

Identifiers

PMID: 11278333
DOI: 10.1074/jbc.M007147200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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