Article
Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells.
Experimental hematology - 1 Jul 2015
von Palffy Sofia, Bulaeva Elizabeth, Babovic Sonja, Kannan Nagarajan, Knapp David J H F, Wei Lisa, Eaves Connie J, Beer Philip A
Abstract excerpt
Inactivating mutations in IKZF1, the gene that encodes the transcription factor IKAROS, are recurrent in poor-prognosis human B-cell leukemias, in which these mutations co-exist with BCR-ABL1 or other genetic changes that activate similar intracellular signaling pathways. However, little is known about the mechanism(s) by which loss of IKAROS activity may co-operate with BCR-ABL1 to transform lymphoid cells. To...
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