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Article

Glycophorin A mutations and risk of secondary leukaemia in patients treated for childhood acute lymphoblastic leukaemia.

British journal of haematology - 1 Apr 1996

Boyse J, Hewitt M, Mott M G

Abstract excerpt

Survivors of child acute lymphoblastic leukaemia (ALL) have a higher than expected risk of developing secondary acute myeloid leukaemia (AML). The glycophorin A (GPA) mutation assay measures the frequency of variant NO and NN erythrocytes in MN heterozygotes. A raised variant frequency (Vf) has been shown in patients treated with chemotherapy known to be at risk of secondary leukaemia. ALL patients were...

Topics

Acute Disease
Child
Child, Preschool
Female
Genetic Markers
Genetic Techniques
Glycophorins
Humans
Leukemia, Myeloid
Male
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8611443
DOI: 10.1046/j.1365-2141.1996.4621001.x

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Glycophorin A mutations and risk of secondary leukaemia in patients treated for childhood acute lymphoblastic leukaemia.PMID 8611443Read ↗

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The GPA in vivo somatic mutation assay.Semantic proximity Read ↗

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The blood-based glycophorin A (GPA) human in vivo somatic mutation assay.Semantic proximity Read ↗

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