Article
Analysis of erythrocyte glycophorin-A variants by flow cytometry in lung disease patients detects the effect of tobacco smoke.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology - 1 Jan 2000
Neri M, Geido E, Filiberti R, Orecchia R, Di Vinci A, Cafferata M, Tassara E, Puntoni R, Giaretti W
Abstract excerpt
The glycophoryn A (GPA) assay evaluates somatic in vivo mutations. It is considered a cumulative biodosimeter for genotoxic exposures and is under evaluation in cancer risk assessment. GPA, a polymorphic membrane protein of the erythrocytes, determines the MN blood groups. The NO and NN variant frequencies (VF) may be detected in MN subjects (about 50% of the population) by flow cytometry using two differently...
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