Article
In vivo somatic mutation and segregation at the human glycophorin A (GPA) locus: phenotypic variation encompassing both gene-specific and chromosomal mechanisms.
Mutation research - 1 Jul 1993
Grant S G, Bigbee W L
Abstract excerpt
The human in vivo GPA assay uses immunolabelling and flow cytometry to directly detect and quantitate somatic variation in erythrocytes expressing glycophorin A (GPA) allele-loss phenotypes in peripheral blood samples from individuals heterozygous for the MN blood type. The assay distinguishes tw...
Topics
- Alleles
- Biological Assay
- DNA
- DNA Damage
- DNA Repair
- Environmental Monitoring
- Flow Cytometry
- Gene Frequency
- Genetic Variation
- Glycophorins
- Heterozygote
- Humans
- MNSs Blood-Group System
- Mutagens
- Recombination, Genetic
- Ultraviolet Rays