Article
The blood-based glycophorin A (GPA) human in vivo somatic mutation assay.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Myers Nicole T, Grant Stephen G
Abstract excerpt
The glycophorin A assay concurrently detects and quantifies erythrocytes with allele-loss phenotypes at the autosomal locus responsible for the polymorphic MN blood group. It uses a pair of allele-specific monoclonal antibodies and flow cytometry to efficiently analyze a standard population of five million cells. Two distinct variant phenotypes are detected: simple allele loss and allele loss followed by...
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