Increased frequency of somatic mutations at glycophorin A loci in patients with aplastic anaemia, myelodysplastic syndrome and paroxysmal nocturnal haemoglobinuria.

doi:10.1046/j.1365-2141.1997.2233037.x

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Article

Increased frequency of somatic mutations at glycophorin A loci in patients with aplastic anaemia, myelodysplastic syndrome and paroxysmal nocturnal haemoglobinuria.

British journal of haematology - 1 Aug 1997

Hattori H, Machii T, Ueda E, Shibano M, Kageyama T, Kitani T

Abstract excerpt

Paroxysmal nocturnal haemoglobinuria (PNH), aplastic anaemia (AA) and myelodysplastic syndrome (MDS) are haemopoietic stem cell disorders. These disorders have some features in common, and a percentage of cases progress to acute leukaemia. We speculated that changes in gene stability are involved...

Topics

Adult
Aged
Anemia, Aplastic
Gene Frequency
Glycophorins
Hemoglobinuria, Paroxysmal
Humans
Middle Aged
Mutation
Myelodysplastic Syndromes

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