Do mutations at the glycophorin A locus in patients treated for childhood Hodgkin's disease predict secondary leukaemia?

doi:10.1016/s0140-6736(94)92027-3

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Article

Do mutations at the glycophorin A locus in patients treated for childhood Hodgkin's disease predict secondary leukaemia?

Lancet (London, England) - 2 Apr 1994

Mott M G, Boyse J, Hewitt M, Radford M

Abstract excerpt

Childhood Hodgkin's disease has a high cure rate but second cancers are common, related to treatment and perhaps genetic predisposition. The glycophorin A (GPA) mutation assay measures the frequency of NO and NN mutant erythrocytes of MN blood-group heterozygous individuals. Mutant frequencies in...

Topics

Adolescent
Adult
Child
Female
Glycophorins
Hodgkin Disease
Humans
Leukemia
Leukemia, Radiation-Induced
Male
Mutation
Neoplasms, Second Primary

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