Frequencies of HPRT- lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors.

doi:10.1016/0027-5107(93)90137-5

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Article

Frequencies of HPRT- lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors.

Mutation research - 1 Sept 1993

Sala-Trepat M, Boyse J, Richard P, Papadopoulo D, Moustacchi E

Abstract excerpt

The mutant frequency of 6-thioguanine resistance (HPRT locus) in circulating T lymphocytes from 23 Fanconi anemia (FA) patients has been determined. The glycophorin A (GPA) in vivo cell mutants assay, which detects allele loss variant phenotypes arising from mutations in erythroid progenitor cell...

Topics

Adolescent
Adult
Child
Child, Preschool
Erythrocytes
Fanconi Anemia
Glycophorins
Humans
Hypoxanthine Phosphoribosyltransferase
Middle Aged
Mutation
T-Lymphocytes

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