Increased glycophorin A somatic cell variant frequency in arsenic-exposed patients of Guizhou, China.

doi:10.1016/j.toxlet.2006.08.008

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Article

Increased glycophorin A somatic cell variant frequency in arsenic-exposed patients of Guizhou, China.

Toxicology letters - 1 Nov 2006

Zhang X J, Chen D X, Xu H H, Zhao M L, Fang N, Du H, Zhou Y S, Cheng M L, Yuan W, Jiang L, Xiao H, Wa Q B, Liu L M, Liu J, Waalkes M P

Abstract excerpt

Exposure to arsenic through domestic burning arsenic-containing coal causes various tumors in a population of Guizhou, China. The glycophorin A (GPA) assay is a human mutation assay detecting somatic variation in erythrocytes expressing the MN blood type, and was used to assess genotoxicity of arsenic-exposed patients. Peripheral blood was collected from 18 adult healthy subjects and 40 arsenic-exposed patients...

Topics

Adult
Alleles
Arsenic
Biomarkers
China
Coal
Environmental Exposure
Erythrocytes
Female
Flow Cytometry
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycophorins

Humans

Immunohistochemistry

Male

Middle Aged

Mutation

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 17029826
DOI: 10.1016/j.toxlet.2006.08.008

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