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Article

Histone-like protein HU and bacterial DNA topology: suppression of an HU deficiency by gyrase mutations.

Journal of molecular biology - 16 Feb 1996

Malik M, Bensaid A, Rouviere-Yaniv J, Drlica K

Abstract excerpt

The abundant bacterial protein called HU has the ability to wrap and bend DNA in vitro, and thus it has long been thought to play a role in DNA supercoiling. In the absence of HU, Escherichia coli formed tiny colonies on agar, rapidly accumulated suppressor mutations, and was hypersensitive to no...

Topics

Alleles
Bacterial Proteins
Chromosome Mapping
DNA Gyrase
DNA Topoisomerases, Type II
DNA, Bacterial
DNA, Superhelical
DNA-Binding Proteins
Escherichia coli
Genes, Bacterial
Mutation
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Suppression, Genetic

Source

Identifiers

PMID: 8609614
DOI: 10.1006/jmbi.1996.0068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8609614-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Histone-like protein HU and bacterial DNA topology: suppression of an HU deficiency by gyrase mutations.PMID 8609614Read ↗

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