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Article

Histone-like protein HU and bacterial DNA topology: suppression of an HU deficiency by gyrase mutations.

Journal of molecular biology - 16 Feb 1996

Malik M, Bensaid A, Rouviere-Yaniv J, Drlica K

Abstract excerpt

The abundant bacterial protein called HU has the ability to wrap and bend DNA in vitro, and thus it has long been thought to play a role in DNA supercoiling. In the absence of HU, Escherichia coli formed tiny colonies on agar, rapidly accumulated suppressor mutations, and was hypersensitive to novobiocin. Three types of evidence implicated gyrase in the suppression of an HU deficiency. First, spontaneous...

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Identifiers

PMID: 8609614
DOI: 10.1006/jmbi.1996.0068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Histone-like protein HU and bacterial DNA topology: suppression of an HU deficiency by gyrase mutations.PMID 8609614Read ↗

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