Heat shock-induced excessive relaxation of DNA in Escherichia coli mutants lacking the histone-like protein HU.

doi:10.1016/s0167-4781(97)00105-x

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Article

Heat shock-induced excessive relaxation of DNA in Escherichia coli mutants lacking the histone-like protein HU.

Biochimica et biophysica acta - 12 Sept 1997

Ogata Y, Inoue R, Mizushima T, Kano Y, Miki T, Sekimizu K

Abstract excerpt

Plasmid DNA in exponentially growing Escherichia coli immediately relaxes after heat shock but the relaxed DNA re-supercoils rapidly, the despite continued presence of the heat shock conditions. We have now obtained genetic evidence indicating that the histone-like protein HU of E. coli is requir...

Topics

Bacterial Proteins
DNA, Bacterial
DNA, Superhelical
DNA-Binding Proteins
Escherichia coli
Heat-Shock Response
Integration Host Factors
Mutation
Nucleic Acid Conformation
Plasmids
Suppression, Genetic

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