Article
Predominance of the metastatic phenotype in hybrids formed by fusion of mouse and human melanoma clones.
Clinical & experimental metastasis - 1 Mar 1996
van Golen K L, Risin S, Staroselsky A, Berger D, Tainsky M A, Pathak S, Price J E
Abstract excerpt
The fusion of mouse and human melanoma cells that were tumorigenic but had different metastatic capabilities resulted in hybrids that were metastatic when injected intravenously or subcutaneously into nude mice, regardless of whether it was the mouse or the human melanoma clone that was metastatic. The H7 hybrid line, formed by fusing murine nonmetastatic K1735 C19 cells with human metastatic A375 C15 cells...
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