Article
Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma.
Cancer research - 1 Dec 1991
Staroselsky A H, Pathak S, Chernajovsky Y, Tucker S L, Fidler I J
Abstract excerpt
The purpose of these studies was to determine whether the metastatic phenotype will dominate when metastatic and nonmetastatic clones of the K-1735 mouse melanoma are hybridized by somatic cell fusion. Three nonmetastatic and three metastatic clones were transfected with DNA from plasmids pSV2neo...
Topics
- Animals
- Cinnamates
- Drug Resistance
- Female
- Hybrid Cells
- Hygromycin B
- Karyotyping
- Lung Neoplasms
- Melanoma, Experimental
- Mice
- Mice, Inbred C3H
- Mice, Nude
- Neomycin
- Neoplasm Metastasis
- Neoplasm Transplantation
- Phenotype
- Specific Pathogen-Free Organisms
- Transfection