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Article

Site-directed Mutagenesis of nm23-H1

1 Oct 1996

Abstract excerpt

We report the first correlation of Nm23 sequence and its tumor metastasis-suppressive capacity using site-directed mutagenesis and an in vitro tumor cell motility assay. MDA-MB-435 human breast carcinoma cells were transfected with a control expression vector (pCMVBamneo), the vector containing the wild type nm23-H1, or the nm23-H1 vector encoding mutations at the following amino acids: serine 44, a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 8810265
DOI: 10.1074/jbc.271.41.25107

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Site-directed Mutagenesis of nm23-H1PMID 8810265Read ↗

Nm23-H1 Suppresses Tumor Cell Motility by Down-regulating the Lysophosphatidic Acid Receptor <i>EDG2</i>Semantic proximity Read ↗

Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function.Semantic proximity Read ↗

The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to MetastasisSemantic proximity Read ↗

NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.Semantic proximity Read ↗

Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability.Semantic proximity Read ↗

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.Semantic proximity Read ↗

Nucleoside diphosphate kinase A/nm23-H1 promotes metastasis of NB69-derived human neuroblastoma.Semantic proximity Read ↗

Inhibitory activity of nm23-H1 on invasion and colonization of human prostate carcinoma cells is not mediated by its NDP kinase activity.Semantic proximity Read ↗

Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression.Semantic proximity Read ↗

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Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1.Semantic proximity Read ↗

Mutation in the nm23 gene is associated with metastasis in colorectal cancer.Semantic proximity Read ↗

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