Article
Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.
Cell - 5 Apr 1991
Leone A, Flatow U, King C R, Sandeen M A, Margulies I M, Liotta L A, Steeg P S
Abstract excerpt
Reduced expression of the nm23 gene in certain rodent model systems and human breast tumors has been correlated with high tumor metastatic potential. To investigate the functional effects of nm23 expression, we have transfected a constitutive murine nm23-1 expression construct into highly metasta...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Neoplasm
- Gene Expression
- Genes, Tumor Suppressor
- Melanoma
- Mice
- Molecular Sequence Data
- Monomeric GTP-Binding Proteins
- NM23 Nucleoside Diphosphate Kinases
- Neoplasm Metastasis
- Neoplasm Transplantation
- Nucleoside-Diphosphate Kinase
- Phenotype
- Protein Biosynthesis
- Proteins