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Article

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.

Cell - 5 Apr 1991

Leone A, Flatow U, King C R, Sandeen M A, Margulies I M, Liotta L A, Steeg P S

Abstract excerpt

Reduced expression of the nm23 gene in certain rodent model systems and human breast tumors has been correlated with high tumor metastatic potential. To investigate the functional effects of nm23 expression, we have transfected a constitutive murine nm23-1 expression construct into highly metastatic K-1735 TK murine melanoma cells. TK clones expressing the exogenous nm23-1 construct exhibited a reduced incidence...

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PMID: 2013093
DOI: 10.1016/0092-8674(91)90404-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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