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Article

Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype.

Oncogene - 23 Oct 1997

Barsky S H, Sternlicht M D, Safarians S, Nguyen M, Chin K, Stewart S D, Hiti A L, Gray J W

Abstract excerpt

The highly metastatic amelanotic C8161 human melanoma line was found to exhibit complete dominance of its undifferentiated and metastatic phenotype in multiple somatic cell hybridization studies designed to bypass the presence of potential tumor suppressor genes. In a three armed approach involvi...

Topics

Animals
Breast Neoplasms
Cell Count
Cell Division
Cell Fusion
Humans
Karyotyping
Melanoma
Melanoma, Amelanotic
Mice
Mice, SCID
Neoplasm Proteins
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 9366525
DOI: 10.1038/sj.onc.1201379

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9366525-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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