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Article

Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype.

Oncogene - 23 Oct 1997

Barsky S H, Sternlicht M D, Safarians S, Nguyen M, Chin K, Stewart S D, Hiti A L, Gray J W

Abstract excerpt

The highly metastatic amelanotic C8161 human melanoma line was found to exhibit complete dominance of its undifferentiated and metastatic phenotype in multiple somatic cell hybridization studies designed to bypass the presence of potential tumor suppressor genes. In a three armed approach involving somatic cell fusions of C8161 with recipient lines of greater differentiation, different lineage, and different...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9366525
DOI: 10.1038/sj.onc.1201379

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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