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Article

Somatic allelic deletion of nm23 in human cancer.

Cancer research - 1 May 1991

Leone A, McBride O W, Weston A, Wang M G, Anglard P, Cropp C S, Goepel J R, Lidereau R, Callahan R, Linehan W M

Abstract excerpt

Tumor progression to the metastatic phenotype is accompanied in certain cell types by reduced expression of the nm23 gene. We have localized human nm23-H1 to chromosome 17 by somatic cell hybrid analysis. Regional localization in the CEPH database and in situ hybridization is reported. Somatic allelic deletion of nm23-H1 was observed in human breast, renal, colorectal, and lung carcinoma DNA samples, as compared...

Topics

Alleles
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Humans
Male
Monomeric GTP-Binding Proteins
NM23 Nucleoside Diphosphate Kinases
Neoplasm Proteins
Neoplasms
Nucleoside-Diphosphate Kinase

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Identifiers

PMID: 2015608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2015608-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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