Article
Mutation in the nm23 gene is associated with metastasis in colorectal cancer.
Cancer research - 15 Feb 1993
Wang L, Patel U, Ghosh L, Chen H C, Banerjee S
Abstract excerpt
The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Colorectal Neoplasms
- DNA Mutational Analysis
- Gene Amplification
- Genes, Tumor Suppressor
- Humans
- Intestinal Mucosa
- Molecular Sequence Data
- Mutation
- Neoplasm Metastasis
- Polymerase Chain Reaction
