Article
Experimental hepatic tumorigenicity by environmental hydrocarbon dibenzo[a,l]pyrene.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer - 1 Jan 1999
Reddy A P, Spitsbergen J M, Mathews C, Hendricks J D, Bailey G S
Abstract excerpt
There is an evident need of low-cost vertebrates to be used in experimental carcinogenesis. Medaka (Oryzias latipes) provide a useful vertebrate model system for investigating tissue tropism of carcinogens and the action mechanisms of environmental contaminants posing a potential risk to human health. Juvenile medaka 2 months of age fed diets containing 100 ppm (dry weight basis) dibenzo[a,l]pyrene (DBP) for 28...
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