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Article

DNA hydrolysis by monoclonal autoantibody BV 04-01.

Applied biochemistry and biotechnology - 1 Jan 2000

Rodkey L S, Gololobov G, Rumbley C A, Rumbley J, Schourov D V, Makarevich O I, Gabibov A G, Voss E W

Abstract excerpt

Monoclonal anti-DNA autoantibody BV 04-01 catalyzed hydrolysis of DNA in the presence of Mg2+. Catalysis was associated with BV 04-01 IgG, Fab, and single-chain-antibody (SCA) proteins. Cleavage of both ss and dsDNA was observed with efficient hydrolysis of the C-rich region of A7C7ATATAGCGCGT2, as well as a preference for cleaving within CG-rich regions of dsDNA. Data on specificity of ssDNA hydrolysis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10826952
DOI: 10.1385/abab:83:1-3:95

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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